The Clemson Tigers will begin their effort to get back into the Top 25 as they host the Syracuse Orange in an ACC showdown on Saturday afternoon.
The Orange have frequently given the Tigers trouble in recent years, and I’m picking them to cover the spread again in my Syracuse vs. Clemson predictions below.
Read on to find out how I see this game playing out in my free college football picks for Saturday, September 20.
Syracuse vs Clemson prediction
Syracuse vs Clemson best bet: Syracuse +16.5 (-105)
The Syracuse Orange isn’t the same team it was when the Orange went 10-3 last year. Kyle McCord immediately made the program viable at a Top 25 level, and while Steve Angeli is filling in admirably.
He leads the nation with 1,072 yards passing, and the Orange haven’t looked nearly as potent on offense, while struggling on defense; even the FCS Colgate Raiders put up 24 points against Syracuse last week.
But the Orange haven’t looked awful, and the line in this game seems to be based more on reputation than reality. The Clemson Tigers are 1-2 on the year, and their only win was an 11-point victory over Troy.
The Tigers have yet to cover in any of their three games this season. Cade Klubnik is only completing 59.1% of his passes, and Clemson is averaging 5.5 yards per play, one of the lowest marks in the FBS.
That’s not the profile of a team that will beat a conference rival by three scores. And for what it’s worth, we’ve seen the Orange play Clemson tight over the past decade, often as a significant underdog.
The Tigers will win this one, but I’m taking Syracuse to cover the number.
Syracuse vs Clemson same-game parlay
While Clemson has yet to cover in any of its three games this year, it has also hit the Under three times in a row, and I expect both trends to continue. But the Tigers will find success against a shaky Syracuse run defense, so I’m taking Adam Randall to hit the Over on his yardage total.
Syracuse vs Clemson SGP
- Syracuse +16.5
- Under 54.5
- Adam Randall Over 90.5
Our deep-ball SGP: Willy Willis!
- The Orange will get on the board at some point in this game, and I like Yasin Willis to be the one to find the endzone on the ground.
Syracuse vs Clemson SGP
- Syracuse +16.5
- Under 54.5
- Adam Randall Over 90.5 rushing yards
- Yasin Willis anytime touchdown scorer
Syracuse vs Clemson odds
- Spread: Syracuse +17.5 (-110) | Clemson -17.5 (-110)
- Moneyline: Syracuse +525 | Clemson -750
- Over/Under: Over 54.5 (-105) | Under 54.5 (-115)
Syracuse vs Clemson trend to know
Syracuse is 5-2 ATS in its last seven meetings with Clemson. Find more college football betting trends for Syracuse vs Clemson.
How to watch Syracuse vs Clemson
| Location | Memorial Stadium, Clemson, SC |
| Date | Saturday, September 20, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | ESPN |
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