Giants vs A's Prediction, Picks & Odds for Tonight’s MLB Game

Our Giants vs. Athletics predictions expect Jacob Lopez and the A's to do just enough to get a win at home.

Ryan Gilbert - Contributor at Covers.com
Ryan Gilbert • Betting Analyst
Jul 6, 2025 • 15:07 ET • 4 min read

MLB

Match starts: 36 mins
ATH
59 %
SF
41 %
EXPERT PICK - MONEYLINE
Athletics -120 Athletics -120
Read Analysis
Jacob Lopez Athletics MLB
Photo By - Imagn Images. Jacob Lopez throws a pitch against the Rays.

The Athletics host the San Francisco Giants in the rubber match of their three-game set on Sunday night in Sacramento.

While San Francisco is the better team, my Giants vs. Athletics prediction targets the home squad in the best MLB picks on Sunday, July 6.

Giants vs A's prediction

My Giants vs A's best bet: Athletics moneyline (-120 at Caesars)

A quick glance at these teams' records (Giants 48-42, Athletics 37-54) might lead some people to take the road underdogs on Sunday night, but a deeper look has me going the other way.

On the mound, the San Francisco Giants have lost Hayden Birdsong’s last four starts, with the righthander allowing 17 ER in 18 1/3 IP in that span. 

On the flip side, southpaw Jacob Lopez has helped the Athletics to victory in five straight starts after dropping his first seven outings. He’s allowed just six runs (four earned) in 26 1/3 in his last five games.

The Giants have also struggled against left-handed starters this season. They’re 8-15 vs. LHP as opposed to 40-27 vs. RHP.

Caesars QuickPick: Our Giants vs A's same-game parlay (SGP)

Athletics moneyline

Over 10

Matt Chapman 2+ total bases

The Over has hit in each of the last five starts for Birdsong and two of the last three for Lopez despite his success. There have already been 22 runs scored through two games in this series, and the ball has been flying at Sutter Health Park this season.

Matt Chapman is still plugging away in his age-32 season. He’s only batting .245 on the year, but he returned from injury to extend his hitting streak to eight games on Saturday. The veteran has 2+ total bases in seven of those games and 10 of his last 18 overall.

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Giants vs A's odds

Giants vs A's live odds

Giants vs A's opening odds

  • Moneyline: Giants +100 | A's -120
  • Run line: Giants +1.5 (-180) | A's -1.5 (+150)
  • Over/Under: Over 10 | Under 10

Odds courtesy of Caesars.

Giants vs A's trend

The Athletics have cashed the moneyline in 11 of their last 21 games for +5.25 units and a 25% ROI. Find more MLB betting trends for Giants vs. A's.

How to watch Giants vs A's and game info

Location Sutter Health Park, Sacramento, CA
Date Sunday, 7-6-2025
First pitch 10:05 p.m. ET
TV NBCS-Bay Area, NBCS-California
Giants starting pitcher Hayden Birdsong
(3-3, 4.3 E0RA)
A's starting pitcher Jacob Lopez
(2-4, 3.89 ERA)

Giants vs A's latest injuries

Giants vs A's weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Ryan Gilbert - Covers
Betting Analyst

Ryan Gilbert brings the passion and pain of being a Philadelphia sports fan. After graduating from Monmouth University with a finance degree, he now uses his statistical background to find inefficiencies in betting markets. With past stops at NHL.com, NBC Sports, and currently at Covers, Ryan's hot picks blend well with the cold ice of a hockey rink.

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