Cardinals vs Cubs Prediction, Picks & Odds for Today’s MLB Game

Ponnaiya's prediction: All eyes will be on Matthew Liberatore as he has a shot at keeping the Cubs in control.

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst
Jul 5, 2025 • 10:55 ET • 4 min read
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This article contains predictions for an old game!

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Matthew Liberatore St. Louis Cardinals MLB
Photo By - Imagn Images. St. Louis Cardinals starting pitcher Matthew Liberatore (52) pitches.

The St. Louis Cardinals face off against the  Chicago Cubs on Saturday afternoon. While I expect Chicago to have success at the plate, my Cardinals vs. Cubs predictions are backing St. Louis starter Matthew Liberatore on a prop that looks mispriced.

Here are my best free MLB picks for NL Central showdown on July 5.

Cardinals vs Cubs prediction

My Cardinals vs Cubs best bet: Matthew Liberatore Under 1.5 walks (-140 at bet365)

The St. Louis Cardinals will send Matthew Liberatore to the hill for today's showdown against the Chicago Cubs. The lefty has a 3.70 ERA with an OBA of .252 through 16 starts.

In Liberatore's last outing, he allowed just three hits across six innings of shutout ball. However, he also walked five batters which is shocking when you consider that he has issued more than 1.5 walks in just two of 16 starts this year. 

Liberatore is in the top fifth percentile in walk rate (4.5%) while the Cubs are 11th in walk rate (8.6%) against southpaws.

That said, Liberatore is also in the bottom 15th percentile in average exit velocity and the bottom 25th percentile in hard hit rate. That's bad news against a hard-hitting Cubs lineup, especially with the wind blowing towards the outfield at 15 mph today. 

Expect Liberatore to either put together a solid start and display his excellent control or get lit up and pulled early — which is also conducive for going below his 1.5 walks prop.

Cardinals vs Cubs same-game parlay (SGP)

Matthew Liberatore Under 1.5 walks

Cubs Team Total Over 5.5

Seiya Suzuki Over 1.5 total bases

The Cubs won 11-3 yesterday afternoon and they've been an offensive juggernaut this year. They are tied for third in the majors in OPS (.775) and are second in runs per game (5.40). 

That combined with the stiff winds blowing towards the outfield at Wrigley today, have me backing the Over on their team total. 

That wind also has me backing Cubs outfielder Seiya Suzuki who is fifth in the majors in total bases (186) and ninth in slugging percentage (.552) total bases. He also slugs .611 with the platoon advantage which he will have against Liberatore today.

Cardinals vs Cubs odds

Cardinals vs Cubs live odds

Cardinals vs Cubs opening odds

  • Moneyline: St. Louis +100 | Chicago -120
  • Run line: St. Louis +1.5 (-200) | Chicago -1.5 (+165)
  • Over/Under: Over 10.5 (-120) | Under 10.5 (+100)

Cardinals vs Cubs trend

The Cubs are 16-5 in their last 21 games at home. Find more MLB betting trends for Cardinals vs. Cubs.

How to watch Cardinals vs Cubs and game info

Location Wrigley Field, Chicago, Illinois
Date Saturday, 7-5-2025
First pitch 2:20 p.m. ET
TV FDSNMW, MARQ
Cardinals starting pitcher Matthew Liberatore
(6-6, 3.70 ERA)
Cubs starting pitcher Jameson Taillon
(7-6, 4.44 ERA)

Cardinals vs Cubs latest injuries

Cardinals vs Cubs weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Rohit Ponnaiya
Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than any analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics and Oscar odds. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez. You can catch Rohit breaking down every UFC event with Joe Osborne on "P4P Picks" on the Covers YouTube channel and he also has regular appearances on "Before You Bet" with Joe. In addition, he's a regular guest on "By The Book" on the Monumental Sports Network and makes guest appearances on VSIN's "The Handle" and CBS Sports. Rohit primarily makes his bets at bet365, which offers a wide variety of prop markets, but also has accounts at several others so he can shop around for the best prices. For Rohit, bankroll management is key. He believes you should never bet what you can't afford to lose and maximize those few betting opportunities where books misprice a line.

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